John F. Kennedy Airport is probably the most well know airport in New York City, and although it is a big airport it is very easy to navigate and get around and is full of shops, restaurants, and entertainment.
There are multiple ways to get to JFK from all around New York city including Taxi, Bus, and the Subway. The JFK AirTrain which connects all of the airport terminals also connects to the New York City Subway at the Jamaica and Howard Beach stations and is the best public transport option from Manhattan, depending on where you are coming from you may also need to change trains to get to the airport.
Catching a Taxi is the most direct way to get to the Airport from any part of NYC and charge a flat fare of US$52, this does not include any tolls or tips.